Program
Session themes:
Topic I Mitochondria, ROS & NAD
Topic II Metabolism and cell senescence
Topic III Nutrient sensing
Topic IV Systems Biology
Topic V Metabolism and stem cell ageing
Thursday, November 9
14.00 Registration open
Location Registration Desk: in opposite of Entrance 11 - nearby the Fountain Patio / Fonteinpatio
Poster mounting open
Location: Blauwe Patio / Blue Patio
17.30 Opening & Welcome (location: Blauwe Zaal / Blue Room)
By the conference directors
Marian Joëls, PhD, Dean/Board of Directors University Medical Center Groningen
James L. Kirkland, MD, PhD, Mayo Clinic Robert and Arlene Kogod Center on Aging
Thomas von Zglinicki, PhD, University Ageing Biology Centre, Newcastle University
17.35 Announcement by the President of the University of Groningen Sibrandes Poppema, MD, PhD
17.45 Keynote lecture
Genetic mapping of targets in mitochondria, metabolism and ageing
Johan Auwerx, MD, PhD, Professor at the Ecole Polytechnique Fédérale, Laboratory of Integrative and Systems
Physiology, Lausanne, Switzerland
18.45 Drinks & Dinner buffet
Location: Fonteinpatio / Fountain Patio
The reception (drinks) is offered to you by the University of Groningen, the Municipality of Groningen and the Province of
Groningen. For the invitation of the reception, click on: Voucher
Friday, November 10
08.00 Registration Open (Red Room)
Topic I Mitochondria, ROS & NAD
08.20 Opening by program director Barbara Bakker (UMCG) & chairs Gabriele Saretzki (Newcastle University) & Ellen Nollen (UMCG)
08.25 The NAD metabolome - Bioenergetics, signalling and emerging therapeutic applications
Mathias Ziegler, MD, PhD, Professor at the University of Bergen, Head of the Department of Biomedicine, Faculty of Medicine,
Bergen, Norway
08.55 Ketone bodies: Signaling metabolites that affect aging and memory
John Newman, MD, PhD, Assistant Professor of Geriatrics, UCSF, San Francisco USA; Visiting Scientist, Buck Institute for
Research on Aging, Novato USA
09.25 Mitochondrial DNA methylation
Marianne G Rots, PhD, Professor of Molecular Epigenetics, Department of Pathology and Medical Biology,
University Medical Center Groningen, Groningen, the Netherlands
09.55 CD38: from mechanism to therapy for aging-related metabolic decline
Eduardo Chini, MD, PhD, Professor of Anesthesiology, Mayo Clinic Robert and Arlene Kogod Center on Aging and
Mayo Clinic Cancer Center, Rochester, Minnesota, USA
10.25 Summary Topic I by chairs
10.30 Coffee break (Blue Patio)
Topic II Metabolism and Cell Senescence
11.00 Opening by chairs Nathan LeBrasseur (Mayo Clinic, Rochester, Minnesota) & Folkert Kuipers (UMCG)
11.05 Cellular Senescence: At the Nexus between Obesity and Metabolic Dysfunction
James L. Kirkland, MD, PhD, Noaber Foundation Professor of Aging Research, Director Mayo Clinic Robert and Arlene Kogod
Center on Aging, Rochester, Minnesota, USA
11.35 Nuclear to Mitochondrial DNA damage signaling in Neurodegeneration and Aging
Vilhelm A. Bohr, MD, PhD, Senior investigator, Laboratory of Molecular Gerontology, National Institute on Aging,
Baltimore, USA
12.05 Pharmacological inhibition of mitochondrial complex I reduces senescence and reverses aging-related regulation of gen
expression in mice
Eugenia Trushina, PhD, Associate Professor, Mitochondrial Neurobiology and Therapeutics Laboratory Mayo Clinic,
Rochester, Minnesota, USA
12.35 Senescence in post-mitotic cells: a telomere-centric story
João Passos, PhD, Associate Professor, Newcastle University Institute for Ageing and Institute for Cell and Molecular
Biosciences, Newcastle University, UK
13.05 Summary Topic II by chairs
13.10-13.25 Poster Pitch by
Ana Patricia Huerta Guevara, University Medical Center Groningen, Groningen
Selma Osmanagic-Myers, University of Natural Resources and Life Sciences, BOKU, Vienna
Mariana Tarrago, Mayo Clinic
13.30 Lunch, Poster viewing and discussion (Blue Patio)
Topic III Nutrient sensing (Red Room)
15.30 Opening by chairs Cor Calkhoven (UMCG) & Diana Jurk (Newcastle University)
15.35 Nutritional modulation of nonhuman primate aging
Rozalyn Anderson, PhD, Associate Professor, Department of Medicine, SMPH, University of Wisconsin-Madison, USA
16.05 Mechanistic insights into mTORC1 and autophagy in cell senescence
Viktor Korolchuk, PhD, Associate Professor, Institute for Cell and Molecular Biosciences, Newcastle University Institute for
Ageing, Newcastle University, UK
16.35 System approaches to the mammalian target of rapamycin (mTOR) network
Kathrin Thedieck, PhD, Associate Professor of Biochemistry & Molecular Biology, Department of Paediatrics, University Medical
Center Groningen, Groningen, the Netherlands
17.05 Developing tools to monitor changes in metabolism in cancer patients
Hilde Jalving, MD, PhD, Medical Oncologist, Department of Medical Oncology, University Medical Center Groningen,
Groningen, the Netherlands
17.35 Summary by chairs
17.40 Closing day 1 by program directors
18.30 Dinner in Restaurant 't Feithuis
The restaurant is situated in the city centre of Groningen (nearby the UMCG).
Saturday, November 11
Topic IV Systems Biology
08.30 Opening by chairs Tamara Tchkonia (Mayo Clinic) & Paul Robbins (Scripps Research Institute, Jupiter, Florida)
08.35 From the control of erythropoiesis to patient-specific anemia treatment
Ursula Klingmüller, PhD, Division Head, Division Systems Biology of Signal Transduction, German Cancer Research Center
(DKFZ), Heidelberg, Germany
09.05 Systems modelling of cell signalling networks in ageing
Daryl Shanley, PhD, Senior Lecturer, Institute for Cell and Molecular Bioscience, Newcastle University, UK
09.35 Multilevel regulation of mitochondrial metabolism during muscle ageing
Barbara Bakker, PhD, Professor of Medical Systems Biology, Department of Pediatrics and Systems Biology Center
for Energy Metabolism and Ageing, University Medical Center Groningen, Groningen, the Netherlands
10.05 Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative life
Matthias Heinemann, PhD, Professor of Biochemistry & Molecular Biology, Microbiology, Faculty of Science and Engineering,
University of Groningen, Groningen, the Netherlands
10.35 Summary by chairs
10.40 Coffee break (Blue Patio)
Topic V Metabolism and stem cell ageing
11.10 Opening by chairs Laura Niedernhofer (Scripps Research Institute) & Gerald de Haan (UMCG)
11.15 Mitochondrial Metabolic Checkpoint, Stem Cell Aging and Rejuvenation
Danica Chen, PhD, Professor of Nutritional Sciences and Toxicology, Department of Nutritional Sciences & Toxicology,
Berkeley University of California, USA
11.45 Epigenetic stress response and stem cell aging
K. Lenhard Rudolph, MD, Head of the research group on 'Stem cell aging' and Scientific Director Leibniz Institute on Aging –
Fritz Lipmann Institute, Jena, Germany
12.15 Using stem cells to understand and model age related macular degeneration
Majlinda Lako, PhD, Professor of Stem Cell Science, Institute of Genetic Medicine, Newcastle University, UK
12.45 Mitochondrial and senescence mechanisms in lung disease: aging at birth?
Y.S. Prakash, MD, PhD, Chair of Physiology and Biomedical Engineering, Mayo Clinic Robert and Arlene Kogod Center
on Aging, Rochester, Minnesota, USA
13.15 Summary by chairs
13.20 Conference closing by conference and program directors followed by Closing lunch (Blue Patio)
Conference directors:
Marian Joëls, PhD
Professor of Neuroscience, Dean/Board of Directors University Medical Center Groningen, Groningen, the Netherlands
James L. Kirkland, MD, PhD
Noaber Foundation Professor of Aging Research, Director Mayo Clinic Robert and Arlene Kogod Center on Aging, Rochester,
Minnesota, USA
Thomas von Zglinicki, PhD
Professor of Cell Gerontology, Director The ABC-Newcastle, University Ageing Biology Centre, Newcastle upon Tyne, United Kingdom
Program directors:
Barbara M. Bakker, PhD
Professor of Medical Systems Biology, Department of Pediatrics and Systems Biology Center for Energy Metabolism and Ageing, University Medical Center Groningen, Groningen, the Netherlands
Eduardo Chini, MD, PhD
Professor of Anesthesiology, Mayo Clinic Robert and Arlene Kogod Center on Aging and Mayo Clinic Cancer Center, Rochester, Minnesota, USA
Thomas von Zglinicki, PhD
Professor of Cell Gerontology, Director The ABC-Newcastle, University Ageing Biology Centre, Newcastle upon Tyne, United Kingdom
Marian Joëls, PhD
Professor of Neuroscience, Dean/Board of Directors University Medical Center Groningen, Groningen, the Netherlands
James L. Kirkland, MD, PhD
Noaber Foundation Professor of Aging Research, Director Mayo Clinic Robert and Arlene Kogod Center on Aging, Rochester,
Minnesota, USA
Thomas von Zglinicki, PhD
Professor of Cell Gerontology, Director The ABC-Newcastle, University Ageing Biology Centre, Newcastle upon Tyne, United Kingdom
Program directors:
Barbara M. Bakker, PhD
Professor of Medical Systems Biology, Department of Pediatrics and Systems Biology Center for Energy Metabolism and Ageing, University Medical Center Groningen, Groningen, the Netherlands
Eduardo Chini, MD, PhD
Professor of Anesthesiology, Mayo Clinic Robert and Arlene Kogod Center on Aging and Mayo Clinic Cancer Center, Rochester, Minnesota, USA
Thomas von Zglinicki, PhD
Professor of Cell Gerontology, Director The ABC-Newcastle, University Ageing Biology Centre, Newcastle upon Tyne, United Kingdom
