Session themes: Topic I Mitochondria, ROS & NAD Topic II Metabolism and cell senescence Topic III Nutrient sensing Topic IV Systems Biology Topic V Metabolism and stem cell ageing
Thursday, November 9 14.00 Registration open Location Registration Desk: in opposite of Entrance 11 - nearby the Fountain Patio / Fonteinpatio Poster mounting open Location: Blauwe Patio / Blue Patio 17.30 Opening & Welcome (location: Blauwe Zaal / Blue Room) By the conference directors Marian Joëls, PhD, Dean/Board of Directors University Medical Center Groningen James L. Kirkland, MD, PhD, Mayo Clinic Robert and Arlene Kogod Center on Aging Thomas von Zglinicki, PhD, University Ageing Biology Centre, Newcastle University 17.35Announcement by the President of the University of Groningen Sibrandes Poppema, MD, PhD 17.45 Keynote lecture Genetic mapping of targets in mitochondria, metabolism and ageing Johan Auwerx, MD, PhD, Professor at the Ecole Polytechnique Fédérale, Laboratory of Integrative and Systems Physiology, Lausanne, Switzerland 18.45 Drinks & Dinner buffet Location: Fonteinpatio / Fountain Patio The reception (drinks) is offered to you by the University of Groningen, the Municipality of Groningen and the Province of Groningen. For the invitation of the reception, click on: Voucher
Friday, November 10 08.00 Registration Open (Red Room) Topic I Mitochondria, ROS & NAD 08.20 Opening by program director Barbara Bakker (UMCG) & chairs Gabriele Saretzki (Newcastle University) & Ellen Nollen (UMCG) 08.25 The NAD metabolome - Bioenergetics, signalling and emerging therapeutic applications Mathias Ziegler, MD, PhD, Professor at the University of Bergen, Head of the Department of Biomedicine, Faculty of Medicine, Bergen, Norway 08.55 Ketone bodies: Signaling metabolites that affect aging and memory John Newman, MD, PhD, Assistant Professor of Geriatrics, UCSF, San Francisco USA; Visiting Scientist, Buck Institute for Research on Aging, Novato USA 09.25 Mitochondrial DNA methylation Marianne G Rots, PhD, Professor of Molecular Epigenetics, Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, the Netherlands 09.55 CD38: from mechanism to therapy for aging-related metabolic decline Eduardo Chini, MD, PhD, Professor of Anesthesiology, Mayo Clinic Robert and Arlene Kogod Center on Aging and Mayo Clinic Cancer Center, Rochester, Minnesota, USA 10.25 Summary Topic I by chairs 10.30 Coffee break (Blue Patio)
Topic II Metabolism and Cell Senescence 11.00 Opening by chairs Nathan LeBrasseur (Mayo Clinic, Rochester, Minnesota) & Folkert Kuipers (UMCG) 11.05 Cellular Senescence: At the Nexus between Obesity and Metabolic Dysfunction James L. Kirkland, MD, PhD, Noaber Foundation Professor of Aging Research, Director Mayo Clinic Robert and Arlene Kogod Center on Aging, Rochester, Minnesota, USA 11.35 Nuclear to Mitochondrial DNA damage signaling in Neurodegeneration and Aging Vilhelm A. Bohr, MD, PhD, Senior investigator, Laboratory of Molecular Gerontology, National Institute on Aging, Baltimore, USA 12.05 Pharmacological inhibition of mitochondrial complex I reduces senescence and reverses aging-related regulation of gen expression in mice Eugenia Trushina, PhD, Associate Professor, Mitochondrial Neurobiology and Therapeutics Laboratory Mayo Clinic, Rochester, Minnesota, USA 12.35 Senescence in post-mitotic cells: a telomere-centric story João Passos, PhD, Associate Professor, Newcastle University Institute for Ageing and Institute for Cell and Molecular Biosciences, Newcastle University, UK 13.05 Summary Topic II by chairs 13.10-13.25 Poster Pitch by Ana Patricia Huerta Guevara, University Medical Center Groningen, Groningen Selma Osmanagic-Myers, University of Natural Resources and Life Sciences, BOKU, Vienna Mariana Tarrago, Mayo Clinic 13.30 Lunch, Poster viewing and discussion (Blue Patio)
Topic III Nutrient sensing (Red Room) 15.30 Opening by chairs Cor Calkhoven (UMCG) & Diana Jurk (Newcastle University) 15.35 Nutritional modulation of nonhuman primate aging Rozalyn Anderson, PhD, Associate Professor, Department of Medicine, SMPH, University of Wisconsin-Madison, USA 16.05 Mechanistic insights into mTORC1 and autophagy in cell senescence Viktor Korolchuk, PhD, Associate Professor, Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Newcastle University, UK 16.35 System approaches to the mammalian target of rapamycin (mTOR) network Kathrin Thedieck, PhD, Associate Professor of Biochemistry & Molecular Biology, Department of Paediatrics, University Medical Center Groningen, Groningen, the Netherlands 17.05 Developing tools to monitor changes in metabolism in cancer patients Hilde Jalving, MD, PhD, Medical Oncologist, Department of Medical Oncology, University Medical Center Groningen, Groningen, the Netherlands 17.35 Summary by chairs 17.40 Closing day 1 by program directors 18.30 Dinner in Restaurant 't Feithuis The restaurant is situated in the city centre of Groningen (nearby the UMCG).
Saturday, November 11 Topic IV Systems Biology 08.30 Opening by chairs Tamara Tchkonia (Mayo Clinic) & Paul Robbins (Scripps Research Institute, Jupiter, Florida) 08.35 From the control of erythropoiesis to patient-specific anemia treatment Ursula Klingmüller, PhD, Division Head, Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany 09.05 Systems modelling of cell signalling networks in ageing Daryl Shanley, PhD, Senior Lecturer, Institute for Cell and Molecular Bioscience, Newcastle University, UK 09.35 Multilevel regulation of mitochondrial metabolism during muscle ageing Barbara Bakker, PhD, Professor of Medical Systems Biology, Department of Pediatrics and Systems Biology Center for Energy Metabolism and Ageing, University Medical Center Groningen, Groningen, the Netherlands 10.05 Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative life Matthias Heinemann, PhD, Professor of Biochemistry & Molecular Biology, Microbiology, Faculty of Science and Engineering, University of Groningen, Groningen, the Netherlands 10.35 Summary by chairs 10.40 Coffee break (Blue Patio)
Topic V Metabolism and stem cell ageing 11.10 Opening by chairs Laura Niedernhofer (Scripps Research Institute) & Gerald de Haan (UMCG) 11.15 Mitochondrial Metabolic Checkpoint, Stem Cell Aging and Rejuvenation Danica Chen, PhD, Professor of Nutritional Sciences and Toxicology, Department of Nutritional Sciences & Toxicology, Berkeley University of California, USA 11.45 Epigenetic stress response and stem cell aging K. Lenhard Rudolph, MD, Head of the research group on 'Stem cell aging' and Scientific Director Leibniz Institute on Aging – Fritz Lipmann Institute, Jena, Germany 12.15 Using stem cells to understand and model age related macular degeneration Majlinda Lako, PhD, Professor of Stem Cell Science, Institute of Genetic Medicine, Newcastle University, UK 12.45 Mitochondrial and senescence mechanisms in lung disease: aging at birth? Y.S. Prakash, MD, PhD, Chair of Physiology and Biomedical Engineering, Mayo Clinic Robert and Arlene Kogod Center on Aging, Rochester, Minnesota, USA 13.15 Summary by chairs 13.20 Conference closing by conference and program directors followed by Closing lunch (Blue Patio)
Conference directors: Marian Joëls, PhD Professor of Neuroscience, Dean/Board of Directors University Medical Center Groningen, Groningen, the Netherlands James L. Kirkland, MD, PhD Noaber Foundation Professor of Aging Research, Director Mayo Clinic Robert and Arlene Kogod Center on Aging, Rochester, Minnesota, USA Thomas von Zglinicki, PhD Professor of Cell Gerontology, Director The ABC-Newcastle, University Ageing Biology Centre, Newcastle upon Tyne, United Kingdom Program directors: Barbara M. Bakker, PhD Professor of Medical Systems Biology, Department of Pediatrics and Systems Biology Center for Energy Metabolism and Ageing, University Medical Center Groningen, Groningen, the Netherlands Eduardo Chini, MD, PhD Professor of Anesthesiology, Mayo Clinic Robert and Arlene Kogod Center on Aging and Mayo Clinic Cancer Center, Rochester, Minnesota, USA Thomas von Zglinicki, PhD Professor of Cell Gerontology, Director The ABC-Newcastle, University Ageing Biology Centre, Newcastle upon Tyne, United Kingdom